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Still, it is one of the most useful practical distinctions between these two medications, and it often shapes the first conversation I have with patients who are deciding between them

The reason behind this is it takes a larger dose to get the same effects as if you were injecting the peptides

Injectable GLP-1s such as Wegovy have also demonstrated cardiovascular risk reduction in high-risk patients, an advantage not yet confirmed for the upcoming oral versions

Bariatric Surgery as a Gold Standard: Bariatric surgery remains the most effective intervention for achieving substantial and sustained weight loss, particularly in patients with severe obesity